Csf1r^tm1.1Jwp
Targeted Allele Detail

Summary

• Symbol: Csf1r^tm1.1Jwp
• Name: colony stimulating factor 1 receptor; targeted mutation 1.1, Jeffrey W Pollard
• MGI ID: MGI:5689434
• Synonyms: Csf1r^dex5, Csf1r^tmdex5jwp
• Gene: Csf1r Location: Chr18:61238644-61264211 bp, + strand Genetic Position: Chr18, 34.41 cM, cytoband D
• Alliance: Csf1r^tm1.1Jwp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110981
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 5, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 5. Cre-mediated recombination removed the neo cassette and exon 5. (J:101977, J:110981)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csf1r Mutation: 63 strains or lines available

References

• Original: J:110981 Li J, et al., Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis. 2006 Jul;44(7):328-35
• All: 6 reference(s)