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Lrp4mdig-3J
Spontaneous Allele Detail
Nomenclature
Symbol: Lrp4mdig-3J
Name: low density lipoprotein receptor-related protein 4; malformed digits 3 Jackson
MGI ID: MGI:5688522
Gene: Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Mutation
origin
Strain of Origin:  B6.129-Reg3gtm1.1Lvh/J
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Single point mutation
 
Mutation detailsA spontaneous C-to-T transition at chromosome 2 position 91,492,644 bp (GRCm38) changes amino acid 1158 from arginine to tryptophan (p.R1158W) in the third beta-propeller domain. (J:222308, J:224655)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:  58 strains or lines available
References
Original:  J:224655 Harris BS, et al., The malformed digits 3 Jackson mutation. MGI Direct Data Submission. 2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory