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Ddhd2tm1Crv
Targeted Allele Detail
Nomenclature
Symbol: Ddhd2tm1Crv
Name: DDHD domain containing 2; targeted mutation 1, Benjamin F Cravatt
MGI ID: MGI:5662251
Gene: Ddhd2  Location: Chr8:25725324-25754474 bp, - strand  Genetic Position: Chr8, 14.17 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216446
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic region including exon 8 was replaced with a neo cassette via homologous recombination. RT-PCR analysis confirmed the absence of mRNA expression in brain tissue from homozygous mice. (J:216446)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddhd2 Mutation:  29 strains or lines available
References
Original:  J:216446 Inloes JM, et al., The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory