Bglu18^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Bglu18^{B6.129P2-Apoe-tm1Unc/J}
• Name: blood glucose level 18; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5662124
• QTL: Bglu18 Location: Chr5:99838468-99838597 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:187953

Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with fasting plasma blood glucose level on a Western diet.

QTL Bglu18 maps to 38.7 - 58.7 cM on Chromosome 5 with a peak LOD score of 4.81 at D5Mit155 (48.7 cM) in linkage with plasma blood glucose level. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to higher plasma blood glucose levels on Western diet with a dominant mode of inheritance.

References

• Original: J:187953 Zhang Z, et al., Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-201
• All: 1 reference(s)