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Rasa1tm2.1Pdk
Targeted Allele Detail
Nomenclature
Symbol: Rasa1tm2.1Pdk
Name: RAS p21 protein activator 1; targeted mutation 2.1, Philip D King
MGI ID: MGI:5661985
Synonyms: Rasa1R780Q
Gene: Rasa1  Location: Chr13:85214780-85289029 bp, - strand  Genetic Position: Chr13, 45.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216433
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsAn R780Q mutation was inserted in exon 18 and an FRT flanked neo cassette was inserted in intron 18 via homologous recombination. Flp mediated recombination removed the neo cassette. This mutation is predicted to abrogate the ability of the protein to promote RAS hydrolysis of bound GTP. (J:216433)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasa1 Mutation:  21 strains or lines available
References
Original:  J:216433 Lubeck BA, et al., Blood Vascular Abnormalities in Rasa1(R780Q) Knockin Mice: Implications for the Pathogenesis of Capillary Malformation-Arteriovenous Malformation. Am J Pathol. 2014 Dec;184(12):3163-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory