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Comttm1(COMT)Xzho
Targeted Allele Detail
Nomenclature
Symbol: Comttm1(COMT)Xzho
Name: catechol-O-methyltransferase; targeted mutation 1, Xianjin Zhou
MGI ID: MGI:5661839
Synonyms: Human COMT Val
Gene: Comt  Location: Chr16:18406882-18426716 bp, - strand  Genetic Position: Chr16, 11.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224284
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Comttm1(COMT)Xzho expresses 1 gene
 
Mutation detailsThe targeting construct was designed to replace the entire endogenous coding region with the human sequence following by a neomycin (neo) resistance cassette. Western blot analysis confirmed the absence of protein expression in the hippocampus and cortex. (J:224284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Comt Mutation:  11 strains or lines available
References
Original:  J:224284 Risbrough V, et al., Generation and characterization of humanized mice carrying COMT158 Met/Val alleles. Neuropsychopharmacology. 2014 Jul;39(8):1823-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory