Comt^{tm1(COMT)Xzho}
Targeted Allele Detail

Summary

• Symbol: Comt^{tm1(COMT)Xzho}
• Name: catechol-O-methyltransferase; targeted mutation 1, Xianjin Zhou
• MGI ID: MGI:5661839
• Synonyms: Human COMT Val
• Gene: Comt Location: Chr16:18225636-18245602 bp, - strand Genetic Position: Chr16, 11.4 cM
• Alliance: Comt^{tm1(COMT)Xzho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Comt^{tm1(COMT)Xzho} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COMT (1312)

  Comt	(MGI:88470)

• Mutation details: The targeting construct was designed to replace the entire endogenous coding region with the human sequence following by a neomycin (neo) resistance cassette. Western blot analysis confirmed the absence of protein expression in the hippocampus and cortex. (J:224284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Comt Mutation: 23 strains or lines available

References

• Original: J:224284 Risbrough V, et al., Generation and characterization of humanized mice carrying COMT158 Met/Val alleles. Neuropsychopharmacology. 2014 Jul;39(8):1823-32
• All: 2 reference(s)