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Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt
Transgene Detail
Nomenclature
Symbol: Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt
Name: transgene insertion A, Astar Winoto
MGI ID: MGI:5661474
Synonyms: BH3 Tg
Transgene: Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe human BCL2 with amino acids 101-103 mutated from glycine-aspartate-aspartate to alanine-alanine-alanine to abolish BH3 domain pro-apoptotic function is under the control of the T cell-specific Cd4 locus control region (LCR). Immunohistochemistry confirmed expression of the transgene in thymocytes. A compensatory downregulation of endogenous mouse Bcl2 in the thymus, lymph nodes, and spleen is seen with transgene expression. Two lines were chosen for analysis, A and B, with similar phenotypes. (J:217939)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:217939 Burger ML, et al., T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. Elife. 2014;3
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory