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Targeted Allele Detail
Symbol: Ccr2tm1.1Dnc
Name: chemokine (C-C motif) receptor 2; targeted mutation 1.1, Donald Cook
MGI ID: MGI:5660875
Gene: Ccr2  Location: Chr9:124101918-124109140 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:223508
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting construct containing DsRed (red fluorescent protein) sequence followed by a loxP-flanked neomycin resistance cassette was used to disrupt the coding region of the gene. RFP fluorescence is not detectable in targeted cells. Cre-mediated recombination removed the upstream floxed neo cassette. (J:223508)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:  23 strains or lines available
Original:  J:223508 Nakano H, et al., Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol. 2013 Jul;6(4):678-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory