Map3k1^tm1Ega
Targeted Allele Detail

Summary

• Symbol: Map3k1^tm1Ega
• Name: mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Ewen Gallagher
• MGI ID: MGI:5660414
• Synonyms: Map3k1^mPHD
• Gene: Map3k1 Location: Chr13:111882962-111945527 bp, - strand Genetic Position: Chr13, 63.36 cM
• Alliance: Map3k1^tm1Ega page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted in intron 6 and a mutated exon 7 replaced exon 7 via homologous recombination. The mutated exon 7 contains substitutions of C438 and I440 with alanines. This mutation inactivates the plant homeodomain (PHD) motif and impairs E3 Ub ligase activity. (J:215973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k1 Mutation: 63 strains or lines available

References

• Original: J:215973 Charlaftis N, et al., The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 3;33(21):2581-96
• All: 1 reference(s)