Ccr7^tm1.1Dnc
Targeted Allele Detail

Summary

• Symbol: Ccr7^tm1.1Dnc
• Name: C-C motif chemokine receptor 7; targeted mutation 1.1, Donald Cook
• MGI ID: MGI:5660365
• Synonyms: Ccr7^gfp
• Gene: Ccr7 Location: Chr11:99035025-99045903 bp, - strand Genetic Position: Chr11, 62.92 cM, cytoband D
• Alliance: Ccr7^tm1.1Dnc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223508
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP-flanked neomycin cassette and sequence encoding Enhanced Green Fluorescent Protein was used to disrupt the coding region of the Ccr7 gene. Transient transfection with a cre-expressing plasmid DNA removed the selection cassette. (J:223508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr7 Mutation: 28 strains or lines available

References

• Original: J:223508 Nakano H, et al., Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol. 2013 Jul;6(4):678-91
• All: 6 reference(s)