Cdkn2a^tm1.1Lshe
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1.1Lshe
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1.1, Lanlan Shen
• MGI ID: MGI:5660270
• Synonyms: p16^cis
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1.1Lshe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215789
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A construct consisting of a loxP site, 140 bp cis element, an FRT flanked neo cassette and a second loxP site was inserted 1 kb upstream of the transcription start site. The cis element contains 3 DNA sequence motifs enriched in methylated promoters. Flp mediated recombination removed the neo cassette. Age-related promoter methylation is increased. (J:215789)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 59 strains or lines available

References

• Original: J:215789 Yu DH, et al., Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest. 2014 Sep 2;124(9):3708-12
• All: 1 reference(s)