Septin7^tm1.1Mgl
Targeted Allele Detail

Summary

• Symbol: Septin7^tm1.1Mgl
• Name: septin 7; targeted mutation 2.1, Matthia Gaestel
• MGI ID: MGI:5660261
• Synonyms: Sept7^del
• Gene: Septin7 Location: Chr9:25163735-25219867 bp, + strand Genetic Position: Chr9, 10.25 cM
• Alliance: Septin7^tm1.1Mgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. A second loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 4. (J:223786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin7 Mutation: 36 strains or lines available

References

• Original: J:223786 Menon MB, et al., Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet. 2014 Aug;10(8):e1004558
• All: 3 reference(s)