Tg(tetO-PRKCG*S361G,-GFP)3Jpka
Transgene Detail

Summary

• Symbol: Tg(tetO-PRKCG*S361G,-GFP)3Jpka
• Name: transgene insertion 3, Josef P Kapfhammer
• MGI ID: MGI:5660027
• Synonyms: PKC-C
• Transgene: Tg(tetO-PRKCG*S361G,-GFP)3Jpka Location: unknown
• Alliance: Tg(tetO-PRKCG*S361G,-GFP)3Jpka page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-PRKCG*S361G,-GFP)3Jpka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKCG (5582)

  Prkcg

  (MGI:97597)

  The cDNA carries the S361G mutation

• Mutation details: The complete coding sequence of the human PRKCG cDNA with the S361G mutation was inserted in the bidirectional pTRE-Tight-BI response plasmid containing aequorea coerulescens green fluorescent protein gene as a reporter. The S361G mutation, located in the kinase domain, is seen in families with spinocerebellar ataxia 14. Five lines were established with line 3 studied further. (J:218354)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:218354 Ji J, et al., Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. Neurobiol Dis. 2014 Oct;70:1-11
• All: 5 reference(s)