Lamtor1^tm1Scli
Targeted Allele Detail

Summary

• Symbol: Lamtor1^tm1Scli
• Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; targeted mutation 1, Sheng-Cai Lin
• MGI ID: MGI:5659960
• Synonyms: LAMTOR1^F
• Gene: Lamtor1 Location: Chr7:101555044-101561110 bp, + strand Genetic Position: Chr7, 54.68 cM, cytoband F1
• Alliance: Lamtor1^tm1Scli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215643
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of the polyA signal following exon 5 via homologous recombination. (J:215643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamtor1 Mutation: 21 strains or lines available

References

• Original: J:215643 Zhang CS, et al., The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 2014 Sep 2;20(3):526-40
• All: 6 reference(s)