Pten^tm2.1Whs
Targeted Allele Detail

Summary

• Symbol: Pten^tm2.1Whs
• Name: phosphatase and tensin homolog; targeted mutation 2.1, Wen H Shen
• MGI ID: MGI:5659854
• Synonyms: Pten^FLAG
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2.1Whs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215278
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted in intron 8 and C-terminal FLAG tag was inserted in exon 9 before the stop codon via homologous recombination. Cre mediated recombination removed the neo cassette. (J:215278)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 81 strains or lines available

References

• Original: J:215278 Liang H, et al., PTENalpha, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell Metab. 2014 May 6;19(5):836-48
• All: 1 reference(s)