Asic1^tm1.1Xen
Targeted Allele Detail

Summary

• Symbol: Asic1^tm1.1Xen
• Name: acid-sensing ion channel 1; targeted mutation 1.1, Taconic Biosciences
• MGI ID: MGI:5659746
• Synonyms: Asic1a^loxP
• Gene: Asic1 Location: Chr15:99568249-99599011 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Asic1^tm1.1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214974
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:214974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic1 Mutation: 44 strains or lines available

References

• Original: J:214974 Kreple CJ, et al., Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci. 2014 Aug;17(8):1083-91
• All: 6 reference(s)