Ap2m1^tm1.1Vha
Targeted Allele Detail

Summary

• Symbol: Ap2m1^tm1.1Vha
• Name: adaptor-related protein complex 2, mu 1 subunit; targeted mutation 1.1, Volker Haucke
• MGI ID: MGI:5649333
• Synonyms: AP-2(mu)^lox
• Gene: Ap2m1 Location: Chr16:20354230-20363659 bp, + strand Genetic Position: Chr16, 12.46 cM, cytoband 16
• Alliance: Ap2m1^tm1.1Vha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP and FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. Flp-meditated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:214740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap2m1 Mutation: 40 strains or lines available

References

• Original: J:214740 Kononenko NL, et al., Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron. 2014 Jun 4;82(5):981-8
• All: 7 reference(s)