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Targeted Allele Detail
Symbol: Krastm4.1Bbd
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4.1, Mariano Barbacid
MGI ID: MGI:5649285
Synonyms: K-RasV14I
Gene: Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:223433
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA PGK-Hyg-STOP (LSL) cassette flanked by loxP sites was inserted 100 bp upstream of a Kras mutagenized exon 1 in which a single base pair substitution of GTA to ATA in the first nucleotide of codon 14 results in the amino acid change of valine for isoleucine (V14I). Cre-mediated recombination in the germline removed the floxed LSL cassette. (J:223433)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  55 strains or lines available
Original:  J:223433 Hernandez-Porras I, et al., K-RasV14I recapitulates Noonan syndrome in mice. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory