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Targeted Allele Detail
Symbol: Krastm4.1Bbd
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4.1, Mariano Barbacid
MGI ID: MGI:5649285
Synonyms: K-RasV14I
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:223433
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA PGK-Hyg-STOP (LSL) cassette flanked by loxP sites was inserted 100 bp upstream of a Kras mutagenized exon 1 in which a single base pair substitution of GTA to ATA in the first nucleotide of codon 14 results in the amino acid change of valine for isoleucine (V14I). Cre-mediated recombination in the germline removed the floxed LSL cassette. (J:223433)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  36 strains or lines available
Original:  J:223433 Hernandez-Porras I, et al., K-RasV14I recapitulates Noonan syndrome in mice. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory