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Targeted Allele Detail
Symbol: Spon1tm1Gdpa
Name: spondin 1, (f-spondin) extracellular matrix protein; targeted mutation 1, Glyn D Palmer
MGI ID: MGI:5648858
Gene: Spon1  Location: Chr7:113765998-114043370 bp, + strand  Genetic Position: Chr7, 59.25 cM
Spon1tm1Gdpa/Spon1tm1Gdpa mice exhibit post-natal accumulation of bone

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:214251
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first coding exon was replaced with an IRES/betaGeo/PolyA cassette via homologous recombination. RT-PCR analysis confirmed the absence of expression in multiple tissues from homozygous mice. (J:214251)
Generation of the Spon1tm1Gdpa allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spon1 Mutation:  19 strains or lines available
Original:  J:214251 Palmer GD, et al., F-spondin deficient mice have a high bone mass phenotype. PLoS One. 2014;9(5):e98388
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory