Tg(TP1-nlacZ)1Cota
Transgene Detail

Summary

• Symbol: Tg(TP1-nlacZ)1Cota
• Name: transgene insertion 1, Michel Cohen-Tannoudji
• MGI ID: MGI:5648725
• Synonyms: NAS, TP1-nlacZ
• Transgene: Tg(TP1-nlacZ)1Cota Location: unknown
• Alliance: Tg(TP1-nlacZ)1Cota page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene with a nuclear localization signal (nls-lacZ) was placed under the control of the TP1 promoter, which consists of 12 multimerized RBP-Jkappa binding motifs upstream from a minimal beta-globin promoter. The TP1 promoter is transactivated in a RBP-Jkappa-dependent manner by the activated forms of the four mammalian Notch receptors, and can be used to detect Notch pathway activity. Only one transgenic line generated was shown to express lacZ and was expanded and studied further. (J:110140)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:110140 Souilhol C, et al., Nas transgenic mouse line allows visualization of Notch pathway activity in vivo. Genesis. 2006 Jun;44(6):277-86
• All: 2 reference(s)