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Dyrk1atm1Jdc
Targeted Allele Detail
Nomenclature
Symbol: Dyrk1atm1Jdc
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a; targeted mutation 1, John D Crispino
MGI ID: MGI:5648391
Synonyms: Dyrk1af
Gene: Dyrk1a  Location: Chr16:94570010-94695517 bp, + strand  Genetic Position: Chr16, 55.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223138
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct contains a loxP site inserted upstream of exon 5 and a FRT-flanked neomycin cassette and a loxP site inserted downstream of exon 6. (J:223138)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dyrk1a Mutation:  76 strains or lines available
References
Original:  J:223138 Thompson BJ, et al., DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015 Jun 1;212(6):953-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory