Slc40a1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Slc40a1^{tm1c(EUCOMM)Hmgu}
• Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5648258
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Slc40a1 gene page

Mutation origin

• Mutant Cell Line: HEPD0551_2_A07
• Germline Transmission: Earliest citation of germline transmission: J:220242
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated recombination of Slc40a1^{tm1a(EUCOMM)Hmgu} removed the lacZ and floxed neomycin selection cassette. Exons 4 and 5 remain floxed. (J:220242)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 54 strains or lines available

References

• Original: J:220242 Lakhal-Littleton S, et al., Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9
• All: 6 reference(s)