Bdh2^tm1.2Lde
Targeted Allele Detail

Summary

• Symbol: Bdh2^tm1.2Lde
• Name: 3-hydroxybutyrate dehydrogenase, type 2; targeted mutation 1.2, L Devireddy
• MGI ID: MGI:5648255
• Gene: Bdh2 Location: Chr3:134986982-135010187 bp, + strand Genetic Position: Chr3, 62.55 cM, cytoband H2
• Alliance: Bdh2^tm1.2Lde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214292
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 7 and a loxP site was inserted downstream of exon 7 via homologous recombination. Cre mediated recombination removed the exon 7 and the neo cassette. (J:214292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdh2 Mutation: 27 strains or lines available

References

• Original: J:214292 Liu Z, et al., Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. J Exp Med. 2014 Jun 2;211(6):1197-213
• All: 2 reference(s)