Hamp^tm1.2Wthg
Targeted Allele Detail

Summary

• Symbol: Hamp^tm1.2Wthg
• Name: hepcidin antimicrobial peptide; targeted mutation 1.2, Benjamin Davies
• MGI ID: MGI:5648237
• Gene: Hamp Location: Chr7:30641793-30643454 bp, - strand Genetic Position: Chr7, 19.27 cM
• Alliance: Hamp^tm1.2Wthg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220242
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. Cre-mediated recombination removed exons 2 and 3. (J:220242)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hamp Mutation: 17 strains or lines available

References

• Original: J:220242 Lakhal-Littleton S, et al., Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9
• All: 1 reference(s)