Tg(MSR1)3Winth
Transgene Detail

Summary

• Symbol: Tg(MSR1)3Winth
• Name: transgene insertion 3, Menno de Winther
• MGI ID: MGI:5648236
• Synonyms: MSR1
• Transgene: Tg(MSR1)3Winth Location: unknown
• Alliance: Tg(MSR1)3Winth page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MSR1)3Winth expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MSR1 (4481)

  Msr1	(MGI:98257)

• Mutation details: A 180-kb YAC fragment containing the entire human MSR1 gene was used to generate transgenic mice expressing the gene under the control of the regulatory elements contained within the YAC. Two founder mice were shown to contain the complete sequence and were bred to generate two lines (lines 2 and 3). Line 3 expresses higher levels of the encoded protein and was expanded and studied further. (J:59667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:59667 de Winther MP, et al., Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages. Atherosclerosis. 1999 Dec;147(2):339-47
• All: 3 reference(s)