Tg(ITGAM-PLA2G2A)1Winth
Transgene Detail

Summary

• Symbol: Tg(ITGAM-PLA2G2A)1Winth
• Name: transgene insertion 1, Menno de Winther
• MGI ID: MGI:5648230
• Synonyms: sPLA2 Tg
• Transgene: Tg(ITGAM-PLA2G2A)1Winth Location: unknown
• Alliance: Tg(ITGAM-PLA2G2A)1Winth page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ITGAM-PLA2G2A)1Winth expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLA2G2A (5320)

  Pla2g2a

  (MGI:104642)

• Mutation details: The human PLA2G2A (sPLA2) gene is expressed under the control of a 1.7 kB human ITGAM (CD11b) promoter. Two transgenic mouse lines were successfully generated. By Northern blot analysis, line 1 mice show expression in liver, spleen, lung, and isolated primary macrophages. Line 2 mice show a similar expression pattern, but at lower levels. Line 1 was expanded and studied further. (J:136941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:136941 Ghesquiere SA, et al., Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition. J Lipid Res. 2005 Feb;46(2):201-10
• All: 1 reference(s)