Tg(tetO-AGTR1*N111G,-lacZ)1Aco
Transgene Detail

Summary

• Symbol: Tg(tetO-AGTR1*N111G,-lacZ)1Aco
• Name: transgene insertion 1, Justin Ainscough
• MGI ID: MGI:5648211
• Synonyms: hAT1R-mut1
• Transgene: Tg(tetO-AGTR1*N111G,-lacZ)1Aco Location: unknown
• Alliance: Tg(tetO-AGTR1*N111G,-lacZ)1Aco page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-AGTR1*N111G,-lacZ)1Aco expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AGTR1 (185)

  Agtr1a	(MGI:87964)
  Agtr1b	(MGI:87965)

• Mutation details: Transgenic mice with inducible cardiomyocyte-specific expression of an N111G mutant form of the human angiotensin II (Ang II) type-1 receptor (hAT1R) showed strong cardiomyocyte-specific LacZ activation in both neonatal and adult hearts, and pulmonary veins when induced. When adults were given dox, the receptor expression was repressed. (J:162208)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:162208 Ainscough JF, et al., Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res. 2009 Feb 15;81(3):592-600
• All: 2 reference(s)