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Tfap2atm2.1Will
Targeted Allele Detail
Nomenclature
Symbol: Tfap2atm2.1Will
Name: transcription factor AP-2, alpha; targeted mutation 2.1, Trevor Williams
MGI ID: MGI:5647993
Synonyms: NEO, Neoflox
Gene: Tfap2a  Location: Chr13:40715302-40738237 bp, - strand  Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88826
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 5 and an frt-flanked neo cassette was inserted after exon 6, followed by another loxP site. RT-PCR analysis indicates that homozygotes contain only 35% of wild-type Tfap2a levels and RNA analysis indicates that the allele generates aberrant transcripts. (J:88826)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfap2a Mutation:  15 strains or lines available
References
Original:  J:88826 Brewer S, et al., Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol. 2004 Mar 1;267(1):135-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory