Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch
Transgene Detail

Summary

• Symbol: Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch
• Name: transgene insertion H, Chun-Ming Chen
• MGI ID: MGI:5647879
• Synonyms: K8-CE^tg, Tg(K18-EGFP;K8-CreER^T)
• Transgene: Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch Location: unknown
• Alliance: Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt8 (MGI:96705)

• Mutation details: The mice promoters contained within a 24 kb intergenic region drive prostate luminal cell-specific expression of the EGFP reporter gene and tamoxifen-inducible cre recombinase gene (cre/ERT), respectively. The cre fusion is followed by a polyadenylation sequence and 2 copies of the chicken beta globin 5' HS4 insulator sequence. 24 kb of the intergenic region that separates the promoters. The pound symbol is used when no line is specified and/or liens are pooled. (J:223065)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt8 (mouse) Summary of all recombinase alleles driven by Krt8. Comparative matrix view of recombinase activities Alliance mouse Krt8 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:223065 Lu TL, et al., Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice. Am J Pathol. 2013 Mar;182(3):975-91
• All: 3 reference(s)