Gt(ROSA)26Sor^{tm1(Med12*)Rajk}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Med12*)Rajk}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Aleksandar Rajkovic
• MGI ID: MGI:5646271
• Synonyms: Met12R^mt
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Med12*)Rajk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222990
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details:

  The targeting construct contains (from 5 to 3) a loxP site, a neomycin cassette, a second loxP site, mouse Med12 cDNA with a G131A missense mutation, a FLAG epitope tag, IRES, and GFP inserted into the Gt(ROSA)26Sor locus. (J:222990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:222990 Mittal P, et al., Med12 gain-of-function mutation causes leiomyomas and genomic instability. J Clin Invest. 2015 Aug 3;125(8):3280-4
• All: 2 reference(s)