Tg(Thy1-PSEN1*M146V)#Jiri
Transgene Detail

Summary

• Symbol: Tg(Thy1-PSEN1*M146V)#Jiri
• Name: transgene insertion, Jill C Richardson
• MGI ID: MGI:5646170
• Synonyms: TPM
• Transgene: Tg(Thy1-PSEN1*M146V)#Jiri Location: unknown
• Alliance: Tg(Thy1-PSEN1*M146V)#Jiri page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-PSEN1*M146V)#Jiri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  The cDNA carries the M146V mutation.

• Mutation details: The murine Thy1 promoter drives the expression of human PSEN1 carrying the M146V mutation. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:91273)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:91273 Howlett DR, et al., Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. Brain Res. 2004 Aug 13;1017(1-2):130-6
• All: 22 reference(s)