Gt(ROSA)26Sor^{tm2(Gli2*)Jmao}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Gli2*)Jmao}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Junhao Mao
• MGI ID: MGI:5646157
• Synonyms: R26Gli2DN
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Gli2*)Jmao} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Gli2*)Jmao} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gli2 (MGI:95728)	An N-terminally truncated activated form of mouse Gli2 is expressed.

• Mutation details: A cDNA fragment encoding and N-terminally truncated activated form of mouse Gli2 (Gli2DN) with a N-terminal 3XFlag tag was inserted into the locus following a LoxP-Neo-4xpA-LoxP stop cassette. Upon cre-mediated recombination, the mutant protein is expressed. (J:216560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:216560 Rajurkar M, et al., Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13;33(46):5370-8
• All: 1 reference(s)