Srxn1^tm1.1Sgrh
Targeted Allele Detail

Summary

• Symbol: Srxn1^tm1.1Sgrh
• Name: sulfiredoxin 1 homolog (S. cerevisiae); targeted mutation 1.1, Sue Goo Rhee
• MGI ID: MGI:5646118
• Gene: Srxn1 Location: Chr2:151947436-151953296 bp, + strand Genetic Position: Chr2, 74.83 cM, cytoband H1
• Alliance: Srxn1^tm1.1Sgrh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:222986)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srxn1 Mutation: 8 strains or lines available

References

• Original: J:213918 Cho CS, et al., Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12043-8
• All: 4 reference(s)