Tg(Krt14-Col18a1)J4Pih
Transgene Detail

Summary

• Symbol: Tg(Krt14-Col18a1)J4Pih
• Name: transgene insertion J4, Taina Pihlajaniemi
• MGI ID: MGI:5645734
• Transgene: Tg(Krt14-Col18a1)J4Pih Location: unknown
• Alliance: Tg(Krt14-Col18a1)J4Pih page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt14-Col18a1)J4Pih expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Col18a1 (MGI:88451)

• Mutation details: A transgenic mouse cDNA construct encoding the signal sequence and C-terminal endostatin part of the type alpha1(XVIII) chain was expressed under the control of the human K14 promoter. Three transgenic founders, K18, G20, and J4, were obtained. Expression in line J4 was the strongest and was studied further. (J:95251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:95251 Elamaa H, et al., Endostatin overexpression specifically in the lens and skin leads to cataract and ultrastructural alterations in basement membranes. Am J Pathol. 2005 Jan;166(1):221-9
• All: 4 reference(s)