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Tg(Pten)1Srn
Transgene Detail
Nomenclature
Symbol: Tg(Pten)1Srn
Name: transgene insertion 1, Manuel Serrano
MGI ID: MGI:5645732
Synonyms: Ptentg
Transgene: Tg(Pten)1Srn  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pten)1Srn expresses 1 gene
 
Mutation detailsTransgenesis was performed using a BAC, RP24-372O16, that includes the complete mouse gene. One line was selected for further analysis that expresses ~2-fold (2.3+/-0.4) the level of Pten mRNA relative to their control littermates across all examined tissues, including brain, heart, liver, lung, kidney, skin, muscle, brown adipose tissue (BAT), and white adipose tissue (WAT), as well as in mouse embryonic fibroblasts (MEFs). (J:182671)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:182671 Ortega-Molina A, et al., Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 2012 Mar 7;15(3):382-94
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory