P4ha2^tm1Jomy
Targeted Allele Detail

Summary

• Symbol: P4ha2^tm1Jomy
• Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide; targeted mutation 1, Johanna Myllyharju
• MGI ID: MGI:5645507
• Gene: P4ha2 Location: Chr11:53991750-54022494 bp, + strand Genetic Position: Chr11, 32.13 cM, cytoband A5-B1
• Alliance: P4ha2^tm1Jomy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ-PKG-neo cassette inserted in-frame into the third exon of the gene after the translation initiation codon via homologous recombination. (J:222764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any P4ha2 Mutation: 26 strains or lines available

References

• Original: J:222764 Aro E, et al., Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I. J Biol Chem. 2015 Jul 3;290(27):16964-78
• All: 3 reference(s)