Prdm11^tm1.1Ahl
Targeted Allele Detail

Summary

• Symbol: Prdm11^tm1.1Ahl
• Name: PR domain containing 11; targeted mutation 1.1, Anders Henrik Lund
• MGI ID: MGI:5645487
• Synonyms: Prdm11 KO
• Gene: Prdm11 Location: Chr2:92802363-92876512 bp, - strand Genetic Position: Chr2, 51.37 cM
• Alliance: Prdm11^tm1.1Ahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221379
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 and 3 were flanked by loxP sites via homolgous recombination. These exons were then deleted by crossing to a germline CMV-cre mouse. (J:221379)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm11 Mutation: 22 strains or lines available

References

• Original: J:221379 Fog CK, et al., Loss of PRDM11 promotes MYC-driven lymphomagenesis. Blood. 2015 Feb 19;125(8):1272-81
• All: 3 reference(s)