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Dyrk1atm1.1Grc
Targeted Allele Detail
Nomenclature
Symbol: Dyrk1atm1.1Grc
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a; targeted mutation 1.1, Gerald R Crabtree
MGI ID: MGI:5645356
Gene: Dyrk1a  Location: Chr16:94370869-94496376 bp, + strand  Genetic Position: Chr16, 55.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP-flanked neomycin resistance cassettes were introduced both 5' and 3' of the exon that encodes the kinase active site (the fifth coding exon). The 5' neomycin cassette was excised with Cre recombinase during vector construction in E. coli. Cre-mediated recombination removed the 3' floxed neo cassette, leaving the kinase active site exon flanked by loxP sites. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dyrk1a Mutation:  100 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory