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Krastm3Bbd
Targeted Allele Detail
Nomenclature
Symbol: Krastm3Bbd
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 3, Mariano Barbacid
MGI ID: MGI:5645350
Synonyms: KrasFSFG12V
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting vector was designed to insert a FRT-flanked PGK-neo-STOP cassette upstream of the Kras (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) initiation codon. This event also introduced two point mutations in codon 12 of exon 1 (GGT to GTA) replacing a glycine residue with a valine (G12V), a mutation commonly found in human tumors. (J:101977)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  35 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory