Ath46^{129S6/SvEvTac-Apoe-tm4Mae}
QTL Variant Detail

Summary

• QTL variant: Ath46^{129S6/SvEvTac-Apoe-tm4Mae}
• Name: atherosclerosis 46; 129S6/SvEvTac-Apoe^tm4Mae
• MGI ID: MGI:5644658
• QTL: Ath46 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: 129S6/SvEvTac-Apoe^tm4Mae

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:208464

Linkage analysis was performed on 137 female (129S6/SvEvTac-Apoe^tm4Mae x D2.129P2(B6)-Apoe^tm1Unc/J)F2 intercross mice using 170 SNP markers to identify QTL associated with atherosclerotic susceptibility (atherosclerotic lesion size at aortic root). Parental strain D2.129P2(B6)-Apoe exhibits higher incidence of atherosclerosis when compared to 129S6/SvEvTac-Apoe.

QTL Ath46 maps to 106 - 150 Mb (61 - 86 cM) on Chromosome 2 with a peak LOD score of 3.9 at 139 Mb (79 cM) in linkage with atheroscleroticlesion size. D2.129P2(B6)-Apoe alleles confer increased susceptibility to atherosclerotic lesion size.

References

• Original: J:208464 Kayashima Y, et al., Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS One. 2014;9(2):e88274
• All: 1 reference(s)