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Map3k15tm1Hijo
Targeted Allele Detail
Nomenclature
Symbol: Map3k15tm1Hijo
Name: mitogen-activated protein kinase kinase kinase 15; targeted mutation 1, Hidenori Ichijo
MGI ID: MGI:5644160
Synonyms: ASK3 KO
Gene: Map3k15  Location: ChrX:159988433-160123351 bp, + strand  Genetic Position: ChrX, 73.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221240
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced the anterior part of exon 1. Western blot analysis confirmed the absence of protein expression in the kidney. (J:221240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Map3k15 Mutation:  11 strains or lines available
References
Original:  J:221240 Naguro I, et al., ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Nat Commun. 2012;3:1285
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory