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Transgene Detail
Symbol: Tg(Cx3cl1*)1Jung
Name: transgene insertion 1, Steffen Jung
MGI ID: MGI:5644036
Synonyms: CX3CL1105delta
Transgene: Tg(Cx3cl1*)1Jung  Location: unknown  
Strain of Origin:  (BALB/c x C57BL/6)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
Tg(Cx3cl1*)1Jung expresses 1 gene
Mutation detailsBacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 120 kb BAC (#RP24147I16) containing the entire mouse Cx3cl1 (chemokine (C-X3-C motif) ligand 1) gene. This BAC was modified to place a nonsense mutation at amino acid 105, in exon 3, followed by a myc-tag. CCL22 and CCL17 sequences were removed from the BAC by restriction digest. The transgene encodes a secreted truncated protein lacking the mucin stalk. (J:178874)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:178874 Kim KW, et al., In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood. 2011 Nov 24;118(22):e156-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory