Gch1^tm1.1Drg
Targeted Allele Detail

Summary

• Symbol: Gch1^tm1.1Drg
• Name: GTP cyclohydrolase 1; targeted mutation 1.1, David Greaves
• MGI ID: MGI:5643694
• Gene: Gch1 Location: Chr14:47391352-47426870 bp, - strand Genetic Position: Chr14, 24.6 cM, cytoband C2-3
• Alliance: Gch1^tm1.1Drg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 that encode for the GTPCH active site were flanked by loxP sites and an FRT flanked neo cassette was inserted in intron 2. Flp mediated recombination removed the neo cassette. (J:219813, J:220265)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gch1 Mutation: 18 strains or lines available

References

• Original: J:220265 McNeill E, et al., Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation. Free Radic Biol Med. 2015 Feb;79:206-16
• All: 12 reference(s)