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Atp13a2tm1.2Wtd
Targeted Allele Detail
Nomenclature
Symbol: Atp13a2tm1.2Wtd
Name: ATPase type 13A2; targeted mutation 1.2, William T Dauer
MGI ID: MGI:5642333
Gene: Atp13a2  Location: Chr4:140986873-141007330 bp, + strand  Genetic Position: Chr4, 73.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221680
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6 x 129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe loxP flanked exons 2 and 3 were removed via cre-mediated recombination, resulting in an insertion of a premature stop codon in exon 4. RT-PCR analysis confirmed absence of RNA in the brain. (J:221680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp13a2 Mutation:  7 strains or lines available
References
Original:  J:221680 Kett LR, et al., alpha-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015 Apr 8;35(14):5724-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory