Fzd2^tm1Eem
Targeted Allele Detail

Summary

• Symbol: Fzd2^tm1Eem
• Name: frizzled class receptor 2; targeted mutation 1, Edward Morrisey
• MGI ID: MGI:5641475
• Synonyms: Fzd2^flox
• Gene: Fzd2 Location: Chr11:102495257-102498884 bp, + strand Genetic Position: Chr11, 66.45 cM
• Alliance: Fzd2^tm1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213915
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The single coding exon was flanked by loxP sites and followed by neomycin cassette that was subsequently removed via flp recombination. (J:213915)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzd2 Mutation: 34 strains or lines available

References

• Original: J:213915 Kadzik RS, et al., Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12444-9
• All: 3 reference(s)