Sting1^tm1.2Camb
Targeted Allele Detail

Summary

• Symbol: Sting1^tm1.2Camb
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 1.2, John C Cambier
• MGI ID: MGI:5639232
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm1.2Camb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette followed by a loxP site was inserted intron 5. A second loxP site was inserted in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 5 floxed. Cre-mediated recombination removed exons 3 through 5. (J:179270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 49 strains or lines available

References

• Original: J:179270 Jin L, et al., MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 1;187(5):2595-601
• All: 47 reference(s)