Dlx1^tm2.1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx1^tm2.1Jlr
• Name: distal-less homeobox 1; targeted mutation 2.1, John L Rubenstein
• MGI ID: MGI:5638878
• Synonyms: Dlx^f
• Gene: Dlx1 Location: Chr2:71358457-71364325 bp, + strand Genetic Position: Chr2, 42.61 cM
• Alliance: Dlx1^tm2.1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188410
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:188410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx1 Mutation: 21 strains or lines available

References

• Original: J:188410 Seybold BA, et al., Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13829-34
• All: 1 reference(s)