Lmnb2^tm1.2Sgy
Targeted Allele Detail

Summary

• Symbol: Lmnb2^tm1.2Sgy
• Name: lamin B2; targeted mutation 1.2, Stephen G Young
• MGI ID: MGI:5638712
• Gene: Lmnb2 Location: Chr10:80737197-80754079 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Lmnb2^tm1.2Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked beta-geo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the reporter cassette. (J:220914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb2 Mutation: 28 strains or lines available

References

• Original: J:220914 Lee JM, et al., Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May;25(10):1666-75
• All: 1 reference(s)