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Targeted Allele Detail
Symbol: Magohtm1a(KOMP)Dlsi
Name: mago homolog, exon junction complex core component; targeted mutation 1a, Debra L Silver
MGI ID: MGI:5638554
Gene: Magoh  Location: Chr4:107879755-107887424 bp, + strand  Genetic Position: Chr4, 50.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:213515
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 107880431 of Chromosome 4 upstream of exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 at position 107881241. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:213515)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Magoh Mutation:  4 strains or lines available
J:213515 used the KOMP vector PRPGS00072_A_G06 to create this allele.
Original:  J:213515 McMahon JJ, et al., Generation of a Magoh conditional allele in mice. Genesis. 2014 Aug;52(8):752-8
All:  1 reference(s)

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MGI 6.12
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