Vdac2^tm1.2Ehyc
Targeted Allele Detail

Summary

• Symbol: Vdac2^tm1.2Ehyc
• Name: voltage-dependent anion channel 2; targeted mutation 1.2, Emily HY Cheng
• MGI ID: MGI:5638534
• Gene: Vdac2 Location: Chr14:21881629-21895947 bp, + strand Genetic Position: Chr14, 11.91 cM
• Alliance: Vdac2^tm1.2Ehyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220951
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1 through 3 and the neomycin resistance cassette inserted. Western blot analysis confirmed the absence of protein expression in thymocytes. (J:220951)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdac2 Mutation: 18 strains or lines available

References

• Original: J:220951 Ren D, et al., The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal. 2009;2(85):ra48
• All: 1 reference(s)